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The complexities of gut health

By Pat Kelly - 11th Nov 2024

gut health

A synopsis of gastrointestinal health and illness, including the role of gut microbiota and psychological factors

Functional gastrointestinal disorders

There is a wide spectrum of symptoms attributable to the gastrointestinal tract (GIT) problems, including abdominal pain, bloating, fullness, nausea, constipation and vomiting. Multiple identifiable organic causes may be responsible for these symptoms, such as cancer in the gastrointestinal tract, inflammatory bowel disease, coeliac disease, peptic ulcer, and disorders of gut motility. For a substantial proportion of patients, however, investigations into the origin of these symptoms does not uncover any specific cause or abnormality. In these cases, symptoms are often referred to as ‘functional’.1

Functional gastrointestinal disorders (FGIDs) can affect any part of the GI tract (ie, irritable bowel syndrome (IBS), functional dyspepsia, and chronic constipation, most commonly). By definition, FGIDs are not linked to any identifiable structural, morphological, or biochemical abnormality, with no biomarkers or imaging findings that can be of assistance in diagnosis.2

Because of this ambiguity, there is a risk of these disorders being thought of as purely psychogenic, and being minimised, despite the significant prevalence and impact of FGIDs. FGIDs cause disruption to work performance, reduced quality of life, psychological comorbidities, and increased healthcare costs. They are increasingly considered to be disorders of gut-brain interaction, which more accurately reflects their scientific basis, and moves away from the stigma associated with the unclear pathophysiology and the term ‘functional’.

In cases where patients and healthcare professionals have considered these disorders to be purely psychological or of little importance, this has often been damaging, physically and emotionally. Due to the fear of being seen as having a psychological disorder, often patients avoid seeking medical intervention, and as a result, their condition is not managed appropriately. Conversely, other patients increase their engagement with healthcare services, seeking a diagnosis that is perceived to be more acceptable.1

The Rome Foundation (a committee of gastroenterologists and academics in the area of gastrointestinal health) has created evidence-based methods to diagnose and classify FGIDs. There are 33 FGIDs in adults, categorised by anatomical location, and defined by a particular cluster of symptoms. Some of the more common FGID diagnoses and appropriate diagnostic tests are presented in Table 1.


There are 33 FGIDs in adults, categorised by anatomical location, and defined by a particular cluster of symptoms

The most recent update of the Rome Foundation classification (Rome IV, 2016), advocated for thinking of these conditions as disorders of gut-brain interaction, and for the acknowledgment of intricate interactions between contributing biological and psychosocial factors. Treatments for FGIDs target management of both gastrointestinal and psychological symptoms, rather than focusing on specific underlying disease mechanisms once a clear organic pathology has been ruled out.

About 50 per cent of people in the Western world meet the criteria for a FGID at any given time. Up to a third of patients will have had potentially unnecessary surgery for the condition, ie, hysterectomy, cholecystectomy.3

DisorderDefinitionTests Required
Functional dysphagiaSensation of abnormal food bolus transit through the oesophagus, no abnormalities present (structural, motor or mucosal)Includes endoscopy, biopsies, barium swallow (radiology)
Functional heartburnRetrosternal burning/pain/discomfort refractory to acid suppression therapy. No reflux or abnormalities presentIncludes endoscopy, biopsies
Functional chest painRecurrent, unexplained retrosternal chest pain, presumably of oesophageal origin. Different to heartburn and not explained by any abnormalityIncludes cardiology assessment, endoscopy, biopsies
Functional dyspepsiaOne or more symptoms of postprandial fullness, early satiety, epigastric pain/burning that are unexplained after investigationEndoscopy, biopsies if alarm bells are present
IBSRecurrent abdominal pain, at least one day a week, linked with defecation/change in bowel habitsIncludes FBC, CRP, coeliac serology
Functional constipationDifficult, infrequent or incomplete defecation, not meeting criteria for IBS; abdominal pain might be present but not predominantIncludes FBC, TFTs, serum calcium
Functional abdominal  bloating and distensionAbdominal fullness, pressure, or trapped gas (bloating) sensations, along with measurable distension, which does not meet the criteria for another disorderIncludes FBC, coeliac serology
Rumination syndromeRepetitive, effortless regurgitation of recently ingested food into the mouth, followed by re-chewing and re-swallowing, or expulsionHigh resolution oesophageal manometry
FGID undefined/unknownBowel symptoms, not attributable to an organic cause, not meeting diagnostic criteria for other FGIDsInvestigations as specified for IBS, functional constipation, functional abdominal bloating
Table 1. Definitions of some of the most common Rome IV FGIDs and confirmatory tests required1

FBC = full blood count, CRP = C-Reactive protein, TFTs = thyroid function tests, IBS = irritable bowel syndrome

Functional gastrointestinal disorders in Ireland

One study in Ireland2 collected data from a gastroenterology clinic with a special interest in FGIDs to ascertain the level and type of these most frequently encountered in this country. In the population of 2,231 patients included in the study, 41 per cent were diagnosed with a FGID using the Rome III diagnostic criteria. Table 2 shows the breakdown of this 41 per cent into different diagnoses.

FGID DiagnosisPercent
IBS41
Functional constipation22.5
Functional dyspepsia21
Functional bloating8.2
Functional abdominal pain syndrome7.9
Rumination syndrome6.4
Aerophagia6
FGID undefined/unknown5.6
Functional heartburn5.6
Table 2: Percentages of various functional gastrointestinal disorder (FGID) diagnoses in an Irish sample2

Sixty per cent of FGID patients presenting at the gastroenterology clinic already had diagnoses of organic gastrointestinal tract (GIT) disorders such as gastroesophageal reflux disease, Helicobacter pylori infection, gastritis, duodenitis, and hiatus hernia. Thirty-six per cent of these were referred to other specialists. The distinctions between various FGIDs can be unclear, and many patients may present with symptoms attributable to more than one FGID.2 Women appeared to present more often, and with a more classical appearance of a FGID (somatic symptoms, fatigue, stress, anxiety as a precipitant) and this may explain partially why, in general, women are diagnosed more readily than men.


The microbiota is specifically the community of 100 trillion micro-organisms that are present in
the human GIT

There are significant overlaps between the occurrence of FGIDs and other disorders like fibromyalgia, atypical migraine, depression and anxiety, chronic low back pain and chronic pelvic pain. Potentially, an increase in health-seeking behaviour may increase the likelihood in diagnosing these comorbid conditions in this population, however, there may be alternative explanations.

Visceral hypersensitivity, abnormal gastrointestinal motility, and psychological disturbances have all been recognised to contribute to the origin FGIDs for many years, but more recently, low-grade intestinal inflammation, increased intestinal permeability, immune activation, and disturbances in the microbiome have also been identified as important contributing factors. We now know that low-grade inflammation and disturbances in the gut microbiome have a greater impact on health status, including the pathogenesis of these comorbid conditions, than previously accepted.1

The gut microbiome

The gut microbiome is the collective genomes of the microorganisms in the GIT environment. The microbiota is specifically the community of 100 trillion microorganisms that are present in the human GIT.4 These gut microbiota perform essential functions, including the fermentation of non-digestible substances like fibre and endogenous mucus. Fermentation in turn encourages the growth of microbes responsible for producing short chain fatty acids (SCFAs, ie, butyrate, acetate and propionate), which play a role in glucose regulation and metabolism through multiple mechanisms, and gases.

Butyrate is the main source of energy for colonocytes, contributes to glucose and energy homeostasis, and prevents gut dysbiosis. Propionate travels to the liver to regulate gluconeogenesis and satiety signalling.

Acetate, the most common SCFA, promotes bacterial growth in the gut, and also plays a role in central appetite regulation when it reaches the periphery. Lower levels of gut microbiota diversity has been associated with conditions like obesity, inflammatory bowel disease, psoriatic arthritis, type 1 and 2 diabetes, atopic eczema, coeliac disease and arterial stiffness: A diverse gut ecosystem appears to be more robust against environmental influences.

Effect of diet on the gut microbiome

Certain dietary products have negative effects on this gut diversity, such as food additives (emulsifiers) and the artificial sweeteners sucralose, aspartame and saccharin. Medication can also have a significant impact on the composition of gut microbiota. Osmotic laxatives, progesterone, TNF alpha inhibitors, proton pump inhibitors and antibiotics have all been shown to impact the gut microbiome.4 Conversely, the microbiota present can influence individual response to chemotherapy and immunotherapy.

Supplementation with probiotics (live bacteria and yeasts) has several beneficial effects. Prebiotics, also beneficial, are composed of substrates that are used selectively by microorganisms (ie, microbiota accessible carbohydrates, fermentable dietary fibre) that confer a health benefit.

Synbiotics are a mix of both pre- and probiotics. Sufficient fibre intake is vital for gut health — in cases of low-fibre diets, as is common in the Western world, there is evidence that the colonic mucus barrier can be damaged, resulting in pathogen susceptibility and inflammation. This is a mechanism for chronic disease pathogenesis.

Probiotics (mostly Bifidobacterium and Lactobacillus species) are included in a variety of foods and dietary supplements, and their therapeutic effect has been broadly studied. Although it has been suggested that the microbes in many probiotic supplements are not able to establish themselves sufficiently in the gut to exert a meaningful effect, they can also impact health through additional mechanisms, such as immune modulation, or the production of bioactive compounds.4

There is evidence for the beneficial effects of probiotic supplementation for a wide range of indications including prevention of diarrhoea, necrotising enterocolitis, acute respiratory tract infections, pulmonary exacerbations in children with cystic fibrosis, and eczema in children. They also improve cardiometabolic parameters and the inflammation marker, C reactive protein, in patients with type 2 diabetes. Unfortunately due to the heterogeneity of research studies to date in terms of type of probiotic, length of treatment period, and range of conditions studied, it is difficult to make any specific recommendations in terms of probiotic regimens.

The microbiome as a health indicator

A new tool called the Gut Microbiome Wellness Index 25 has been developed. This tool is able to identify changes in gut health that occur before serious symptoms arise, with the aim of enabling a proactive response through dietary and lifestyle changes to prevent the development of poor health, ie, an ‘early warning system’. Early detection of gut imbalances can offer the opportunity to enhance wellness and prevent disease.6

Data from publicly available stool metagenome (gut microbiome) samples provided by both healthy (5,547) and non-healthy people (2,522) were used to create the dataset for analyses.5 The tool has an over 80 per cent accuracy in distinguishing between healthy individuals and those with diseases, providing a standardised index to quantitatively measure how healthy a person’s gut is.

The creators of this tool intend to develop it further using AI techniques to improve its accuracy, and broaden its dataset to include even more diverse samples of healthy and unhealthy populations. This is a great step towards being able to use information from our gut to not only inform about digestive issues and gut health, but in a much broader way to decipher and identify more complex disease states.

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